Oklahoma State vs. Houston Prediction, Odds, Picks for College Football Week 7

No. 20 Houston takes on No. 18 Oklahoma State in a top 25 matchup on Saturday in Week 7 college football on FOX.

Let’s take a look at the odds for No. 18 Oklahoma State vs. No. 20 Houston at DraftKings Sportsbook as of Oct. 17.

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Moneyline

• No. 18 Oklahoma State: +160
• No. 20 Houston: -192

Spread

• No. 18 Oklahoma State +4.5: -110
• No. 20 Houston -4.5: -110

Over/Under

• Over 62.5: -110
• Under 62.5: -110

From FOX Sports Research: 

• Oklahoma State’s Drew Mestemaker is the Big 12’s second-leading passer (1,575) and Houston’s Conner Weigman is third with 1,428.
• Oklahoma State is the Big 12’s leading offense, averaging 521.4 yards per game, while Houston is sitting in third, averaging 481.8. Both teams are top three in scoring: Houston – 40.0, Oklahoma State – 38.2.
• Since 1969-70, no team has won in consecutive years in this series. Last season, Houston won 39-17.

How to Watch No. 18 Oklahoma State vs. No. 20 Houston 

• Date: Saturday, Oct. 17, 2026
• Time: 7:30 p.m. ET
• TV: FOX
• Stream: Watch 3 days free on FOX One, FOXSports.com, FOX Sports App
• Location: TDECU Stadium, Houston, TX