2026 MLB ALDS Odds: White Sox Favored After Game 1 Win

Two AL Central rivals will face off with a trip to the American League Championship Series on the line.

Let’s check out the Guardians-White Sox divisional series odds at DraftKings Sportsbook as of Oct. 4, along with what to know about the matchup.

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White Sox: -190 (bet $10 to win $15.26 total)
Guardians: +160 (bet $10 to win $26 total)

White Sox win 3-1: +260 (bet $10 to win $36 total)
Guardians win 3-2: +295 (bet $10 to win $39.50 total)
White Sox win 3-0: +310 (bet $10 to win $41 total)
White Sox win 3-2: +475 (bet $10 to win $58.50 total)
Guardians win 3-1: +500 (bet $10 to win $60 total)

Spread: Guardians -1.5 (CHW covers)
O/U: 7 (Under hits)

Spread: Guardians -1.5
Moneyline: Guardians -157, White Sox +130
O/U: 6.5

Here’s what to know about the Guardians-White Sox odds:

Game 1: The White Sox have yet to lose in this postseason. They swept the Astros in the wild-card round, and then took Game 1 on the road in Cleveland, 3-0. Pitching carried the day for Chicago to open the series, as its staff allowed just three hits. Munetaka Murakami hit a 2-run homer in the top of the fourth inning, and Colson Montgomery hit an RBI double in the top of the seventh, and that was all the Sox needed. Game 2 is set for Monday.

Playoff History: With that series victory over the Astros, the White Sox got their first playoff win since 2005 — the same year they last won the World Series. As for the Guardians, they’ve made it to the postseason in three of the last four years. They lost in the wild card last year, the ALCS in 2024 and the ALDS in 2022. Their last World Series appearance came in 2016, a seven-game loss to the Cubs.