Alas, preseason is over. No more dress rehearsals. The real deal is here.
It’s time to start making some bets on real games.
The defending Super Bowl champion Philadelphia Eagles kicked things off Thursday night with a 24-20 win over the rival Dallas Cowboys.
Now the spotlight shifts to São Paulo, where the Kansas City Chiefs and Los Angeles Chargers meet Friday in the NFL’s second-ever regular-season game in South America.
With a loaded Week 1 slate, let’s check out the lines for each game at DraftKings Sportsbook as of Sept. 5.
(All times ET)
2025 NFL Week 1 Odds
THURSDAY, SEPT. 4
COWBOYS @ EAGLES (8:20 p.m., NBC)
Philadelphia Eagles 24, Dallas Cowboys 20
FRIDAY, SEPT. 5
CHIEFS @ CHARGERS (8:15 p.m., YouTube)
Point spread: Chiefs -3 (Chiefs favored to win by 3 points or more, otherwise Chargers cover)
Moneyline: Chiefs -165 favorites to win (bet $10 to win $16.06 total); Chargers +140 underdogs to win (bet $10 to win $24.00 total)
Total Over/Under: 46.5 points scored by both teams combined
SUNDAY, SEPT. 7
RAIDERS @ PATRIOTS (1 p.m., CBS)
Point spread: Patriots -2.5 (Patriots favored to win by 2.5 points or more, otherwise Raiders cover)
Moneyline: Patriots -155 favorites to win (bet $10 to win $16.45 total); Raiders +130 underdogs to win (bet $10 to win $23.00 total)
Total Over/Under: 44.5 points scored by both teams combined
STEELERS @ JETS (1 p.m., CBS)
Point spread: Steelers -3 (Steelers favored to win by 3 points or more, otherwise Jets cover)
Moneyline: Steelers -148 favorites to win (bet $10 to win $16.76 total); Jets +124 underdogs to win (bet $10 to win $22.40 total)
Total Over/Under: 37.5 points scored by both teams combined
DOLPHINS @ COLTS (1 p.m., CBS)
Point spread: Colts -1.5 (Colts favored to win by 1.5 points or more, otherwise Dolphins cover)
Moneyline: Colts -112 favorites to win (bet $10 to win $18.93 total); Dolphins -108 underdogs to win (bet $10 to win $19.26 total)
Total Over/Under: 47.5 points scored by both teams combined
CARDINALS @ SAINTS (1 p.m., CBS)
Point spread: Cardinals -6.5 (Cardinals favored to win by 6.5 points or more, otherwise Saints cover)
Moneyline: Cardinals -298 favorites to win (bet $10 to win $13.36 total); Saints +240 underdogs to win (bet $10 to win $34 total)
Total Over/Under: 43.5 points scored by both teams combined
GIANTS @ COMMANDERS (1 p.m., FOX and FOX Sports app)
Point spread: Commanders -5.5 (Commanders favored to win by 5.5 points or more, otherwise Giants cover)
Moneyline: Commanders -258 favorites to win (bet $10 to win $13.88 total); Giants +210 underdogs to win (bet $10 to win $31.00 total)
Total Over/Under: 45.5 points scored by both teams combined
PANTHERS @ JAGUARS (1 p.m., FOX and FOX Sports app)
Point spread: Jaguars -3.5 (Jaguars favored to win by 3.5 points or more, otherwise Panthers cover)
Moneyline: Jaguars -185 favorites to win (bet $10 to win $15.41 total); Panthers +154 underdogs to win (bet $10 to win $25.40 total)
Total Over/Under: 46.5 points scored by both teams combined
BENGALS @ BROWNS (1 p.m., FOX and FOX Sports app)
Point spread: Bengals -5.5 (Bengals favored to win by 5.5 points or more, otherwise Browns cover)
Moneyline: Bengals -250 favorites to win (bet $10 to win $14.00 total); Browns +205 underdogs to win (bet $10 to win $30.50 total)
Total Over/Under: 48.5 points scored by both teams combined
BUCCANEERS @ FALCONS (1 p.m., FOX and FOX Sports app)
Point spread: Buccaneers -1.5 (Buccaneers favored to win by 1.5 points or more, otherwise Falcons cover)
Moneyline: Buccaneers -130 favorites to win (bet $10 to win $17.69 total); Falcons +110 underdogs to win (bet $10 to win $21.00 total)
Total Over/Under: 47.5 points scored by both teams combined
TITANS @ BRONCOS (4:05 p.m., FOX and FOX Sports app)
Point spread: Broncos -8.5 (Broncos favored to win by 8.5 points or more, otherwise Titans cover)
Moneyline: Broncos -395 favorites to win (bet $10 to win $12.53 total); Titans +310 underdogs to win (bet $10 to win $41.00 total)
Total Over/Under: 42.5 points scored by both teams combined
49ERS @ SEAHAWKS (4:05 p.m., FOX and FOX Sports app)
Point spread: 49ers -1.5 (49ers favored to win by 1.5 points or more, otherwise Seahawks cover)
Moneyline: 49ers -125 favorites to win (bet $10 to win $18.00 total); Seahawks +105 underdogs to win (bet $10 to win $20.50 total)
Total Over/Under: 43.5 points scored by both teams combined
LIONS @ PACKERS (4:25 p.m., CBS)
Point spread: Packers -2.5 (Packers favored to win by 2.5 points or more, otherwise Lions cover)
Moneyline: Packers -148 favorites to win (bet $10 to win $16.76 total); Lions +124 underdogs to win (bet $10 to win $22.40 total)
Total Over/Under: 47.5 points scored by both teams combined
TEXANS @ RAMS (4:25 p.m., CBS)
Point spread: Rams -3 (Rams favored to win by 3 points or more, otherwise Texans cover)
Moneyline: Rams -166 favorites to win (bet $10 to win $16.02 total); Texans +140 underdogs to win (bet $10 to win $24.00 total)
Total Over/Under: 43.5 points scored by both teams combined
RAVENS @ BILLS (8:20 p.m., NBC)
Point spread: Ravens -1.5 (Ravens favored to win by 1.5 points or more, otherwise Bills cover)
Moneyline: Ravens -125 underdogs to win (bet $10 to win $18.00 total); Bills +105 favorites to win (bet $10 to win $20.50 total)
Total Over/Under: 50.5 points scored by both teams combined
MONDAY, SEPT. 8
VIKINGS @ BEARS (8:15 p.m., ESPN)
Point spread: Vikings -1.5 (Vikings favored to win by 1.5 points or more, otherwise Bears cover)
Moneyline: Vikings -122 favorites to win (bet $10 to win $18.20 total); Bears +102 underdogs to win (bet $10 to win $20.20 total)
Total Over/Under: 43.5 points scored by both teams combined
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