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Positive Results from Phase 3 OptiTROP-Lung04 Trial of Sacituzumab Tirumotecan Presented at ESMO Presidential Symposium and Simultaneously Published in NEJM Accessibility Statement Skip Navigation In the OptiTROP-Lung04 trial, a total of 376 patients were randomized (1:1) to receive sac-TMT monotherapy or chemotherapy. As at the data cut-off date July 06, 2025, the median follow-up is 18.9 months. the median Progression-Free Survival (PFS) was 8.3 months in the sac-TMT group and 4.3 months in the chemotherapy group. Sac-TMT significantly improved PFS over chemotherapy with 51% lower risk of disease progression or death (hazard ratio…

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ARLINGTON, Texas – What if your quarterback has an MVP-caliber season, but your defense is so bad you can’t even make the playoffs? Call it the Joe Burrow effect.It was one thing when the Cowboys scored 40 and managed only a tie against the Packers, another when they scored 27 and still lost to the Panthers.So, this past week, in defensive meetings, the message was clear and urgent for Dallas players: Don’t let an amazing season by Dak Prescott get buried in high-scoring losses.”We talk about it all the time: When you’ve got an offense like this, that’s a championship…

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While the National League Championship Series was decided with the minimum, the AL counterpart will go the maximum. With a chance to reach the World Series for the first time in their franchise’s history Sunday night in Toronto, the Mariners were stifled in Game 6 of the ALCS by a 22-year-old rookie starter who had other ideas in a 6-2 Blue Jays win, setting up a winner-take-all Game 7 on Monday night. Here are my takeaways: 1. With the season on the line, Jays’ rookie wins the battle The last time Trey Yesavage and Logan Gilbert faced off in Game 2, neither left with…

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Each week, we’ll offer up the very best of the NFL for a given week, kind of like the fantasy football team you wished you had.We’ll pick one quarterback, two running backs, two receivers and a tight end – OK, this is sounding a lot like a super-hindsight fantasy football team – as a way to look back on the weekend that was.A star running back returns to the team, while the quarterback finally got his passing game going to the point that one of his receivers ended up on this list with him.I hear you already, pointing out that…

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NASHVILLE, Tenn. — In the Music City on Sunday, Drake Maye kicked his early-season case for MVP into high gear. The second-year quarterback was historically efficient in the Patriots’ dominant 31-13 victory over the Titans, completing 21 of 23 passes for 222 yards and two touchdowns with a 135.9 passer rating before exiting in the fourth quarter with the game in control. Maye’s 91.3% completion rate was the highest in a game in Patriots history (minimum of 20 pass attempts). He also added eight carries for 62 yards. He’s the first quarterback in the Super Bowl era to complete 90% of his…

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